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Screen-printed electrochemical biosensor based on a ternary Co@MoS2/rGO functionalized electrode for high-performance non-enzymatic glucose sensing

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Abstract

In this study, cobalt oxides functionalized MoS2/reduced graphene oxide was synthesized via a facile one-pot hydrothermal approach. Morphology and crystal structure of this ternary nanoarchitecture were characterized through scanning electron microscopy, transmission electron microscopy, Raman spectra and X-ray photoelectron spectroscopy. An ultrasensitive non-enzymatic glucose sensor was developed by decorating this ternary nanohybrid on the working electrode of a screen-printed electrochemical sensor. Cycle sweep voltammetry and amperometry were used to study the electro-catalytic activity of the modified working electrode, which demonstrated superior catalytic activity towards glucose oxidation with an extremely low detection limit of 30 nM. Meanwhile, this sensor showed an excellent selectivity in the presence of interfering species such as uric acid, ascorbic acid, etc. Based on the screen-printed technique, enzyme mimic nanomaterials could be easily introduced into portable devices, which opens the way to take non-enzymatic glucose electrochemical sensing towards point-of-care.

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References

  • F. Arduini, L. Micheli, D. Moscone, G. Palleschi, S. Piermarini, F. Ricci, G. Volpe, Electrochemical biosensors based on nanomodified screen-printed electrodes: Recent applications in clinical analysis. Trends Anal. Chem. 79, 114–126 (2016)

    Article  Google Scholar 

  • Y.H. Chang, C.T. Lin, T.Y. Chen, C.L. Hsu, Y.H. Lee, W. Zhang, K.H. Wei, L.J. Li, Highly efficient electrocatalytic hydrogen production by MoSx grown on graphene-protected 3D Ni foams. Adv. Mater. 25, 756–760 (2013)

    Article  Google Scholar 

  • C. Chen, Q. Xie, D. Yang, H. Xiao, Y. Fu, Y. Tan, S. Yao, Recent advances in electrochemical glucose biosensors: A review. RSC Adv. 3, 4473–4491 (2013)

    Article  Google Scholar 

  • Z. Chu, J. Peng, W. Jin, Advanced nanomaterial inks for screen-printed chemical sensors. Sensors Actuators B Chem. 243, 919–926 (2017)

    Article  Google Scholar 

  • L.T. Hoa, J.S. Chung, S.H. Hur, A highly sensitive enzyme-free glucose sensor based on Co3O4 nanoflowers and 3D graphene oxide hydrogel fabricated via hydrothermal synthesis. Sensors Actuators B Chem. 223, 76–82 (2016)

    Article  Google Scholar 

  • J. Huang, Z. Dong, Y. Li, J. Li, W. Tang, H. Yang, J. Wang, Y. Bao, J. Jin, R. Li, MoS2 nanosheet functionalized with cu nanoparticles and its application for glucose detection. Mater. Res. Bull. 48, 4544–4547 (2013)

    Article  Google Scholar 

  • J. Huang, Y. He, J. Jin, Y. Li, Z. Dong, R. Li, A novel glucose sensor based on MoS2 nanosheet functionalized with Ni nanoparticles. Electrochim. Acta 136, 41–46 (2014)

    Article  Google Scholar 

  • D.W. Hwang, S. Lee, M. Seo, T.D. Chung, Recent advances in electrochemical non-enzymatic glucose sensors-a review. Anal. Chim. Acta 1033, 1–34 (2018)

    Article  Google Scholar 

  • W.J. Hyun, O.O. Park, B.D. Chin, Foldable graphene electronic circuits based on paper substrates. Adv. Mater. 25, 4729–4734 (2013)

    Article  Google Scholar 

  • J.M. Jeong, M. Yang, D.S. Kim, T.J. Lee, B.G. Choi, D.H. Kim, High performance electrochemical glucose sensor based on three-dimensional MoS2/graphene aerogel. J. Colloid Interface Sci. 506, 379–385 (2017)

    Article  Google Scholar 

  • C. Karuppiah, S. Palanisamy, S.M. Chen, V. Veeramani, P. Periakaruppan, Direct electrochemistry of glucose oxidase and sensing glucose using a screen-printed carbon electrode modified with graphite nanosheets and zinc oxide nanoparticles. Microchim. Acta 181, 1843–1850 (2014)

    Article  Google Scholar 

  • X. Li, L. Zhang, X.B. Zang, X.M. Li, H.W. Zhu, Photo-promoted platinum nanoparticles decorated MoS2@graphene woven fabric catalyst for efficient hydrogen generation. ACS Appl. Mater. Interfaces 8, 10866–10873 (2016)

    Article  Google Scholar 

  • X. Li, K. Ren, M. Zhang, W. Sang, D. Sun, T. Hu, Z. Ni, Cobalt functionalized MoS2/carbon nanotubes scaffold for enzyme-free glucose detection with extremely low detection limit. Sensors Actuators B Chem. 293, 122–128 (2019)

    Article  Google Scholar 

  • L. Ma, Y. Hu, G. Zhu, R. Chen, T. Chen, H. Lu, Y. Wang, J. Liang, H. Liu, C. Yan, Z. Tie, Z. Jin, J. Liu, In situ thermal synthesis of inlaid ultrathin MoS2/graphene nanosheets as electrocatalysts for the hydrogen evolution reaction. Chem. Mater. 28, 5733–5742 (2016)

    Article  Google Scholar 

  • H.M. Mohamed, Screen-printed disposable electrodes: Pharmaceutical applications and recent developments. Trends Anal. Chem. 82, 1–11 (2016)

    Article  Google Scholar 

  • R. Muszynski, B. Seger, P.V. Kamat, In situ synthesis of metal nanoparticles on single-layer graphene oxide and reduced graphene oxide surfaces. J. Phys. Chem. C 112, 5263–5266 (2008)

    Article  Google Scholar 

  • X. Niu, M. Lan, H. Zhao, C. Chen, Highly sensitive and selective nonenzymatic detection of glucose using three-dimensional porous nickel nanostructures. Anal. Chem. 85, 3561–3569 (2013)

    Article  Google Scholar 

  • L. Qiang, S. Vaddiraju, D. Patel, F. Papadimitrakopoulos, Edge-plane microwire electrodes for highly sensitive H2O2 and glucose detection. Biosens. Bioelectron. 26, 3755–3760 (2011)

    Article  Google Scholar 

  • H.S.S. Ramakrishna Matte, A. Gomathi, A.K. Manna, D.J. Late, R. Datta, S.K. Pati, C.N.R. Rao, MoS2 and WS2 analogues of Graphene. Angew. Chem. Int. Ed. 49, 4059–4062 (2010)

    Article  Google Scholar 

  • K. Shavanova, Y. Bakakina, I. Burkova, I. Shtepliuk, R. Viter, A. Ubelis, V. Beni, N. Starodub, R. Yakimova, V. Khranovskyy, Application of 2D non-graphene materials and 2D oxide nanostructures for biosensing technology. Sensors 223, 1–23 (2016)

    Google Scholar 

  • X. Shi, H. Gong, Y. Li, Graphene-based magnetic plasmonic nanocomposite for dual bioimaging and photothermal therapy. Biomaterials. 34, 4786–4793 (2013)

    Article  Google Scholar 

  • Y. Shu, B. Li, J. Chen, Q. Xu, H. Pang, X. Hu, Facile synthesis of ultrathin nickel−cobalt phosphate 2D nanosheets with enhanced electrocatalytic activity for glucose oxidation. ACS Appl. Mater. Interfaces 10, 2360–2367 (2018)

    Article  Google Scholar 

  • H. Song, Y. Ni, S. Kokot, Investigations of an electrochemical platform based on the layered MoS2-graphene and horseradish peroxidase nanocomposite for direct electrochemistry and electrocatalysis. Biosens. Bioelectron. 56, 137–143 (2014)

    Article  Google Scholar 

  • A.T.E. Vilian, B. Dinesh, M. Rethinasabapathy, S.K. Hwang, C.S. Jin, Y.S. Huh, Y.K. Han, Hexagonal Co3O4 anchored reduced graphene oxide sheets for high-performance supercapacitors and non-enzymatic glucose sensing. J. Mater. Chem. A 6, 14367–14379 (2018)

    Article  Google Scholar 

  • H. Vrubel, D. Merki, X. Hu, Hydrogen evolution catalyzed by MoS3 and MoS2 particles. Energy Environ. Sci. 5, 6136–6144 (2012)

    Article  Google Scholar 

  • J. Wang, Electrochemical glucose biosensors. Chem. Rev. 108, 814–825 (2008)

    Article  Google Scholar 

  • Y.H. Wang, K.J. Huang, X. Wu, Recent advances in transition-metal dichalcogenides based electrochemical biosensors: A review. Biosens. Bioelectron. 97, 305–316 (2017)

    Article  Google Scholar 

  • A. Washe, P. Lozano-Sanchez, D. Bejarano-Nosas, Facile and versatile approaches to enhancing electrochemical performance of screen printed electrodes. Electrochim. Acta 91, 166–172 (2013)

    Article  Google Scholar 

  • R. Wilson, Glucose oxidase: an ideal enzyme. Biosens. Bioelectron. 7, 165–185 (1992)

    Article  Google Scholar 

  • J. Xu, F. Li, D. Wang, M. Hasnain Nawaz, Q. An, D. Han, L. Niu, Co3O4 nanostructures on flexible carbon cloth for crystal plane effect of nonenzymatic electrocatalysis for glucose. Biosens. Bioelectron. 123, 25–29 (2019)

    Article  Google Scholar 

  • K. Yamanaka, M.C. Vestergaard, E. Tamiya, Printable electrochemical biosensors: A focus on screen-printed electrodes and their application. Sensors 16, 1761 (2016)

    Article  Google Scholar 

  • J. Yoon, T. Lee, B. Bapurao G, J. Jo, B.K. Oh, J.W. Choi, Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure. Biosens. Bioelectron. 93, 14–20 (2017)

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Key Scientific Instrument and Equipment Development Project (Grant No.: 51627808), National Natural Science Foundation of China (Grant No. 51605088), Natural Science Foundation of Jiangsu Province (Grant No. BK20170667) and Shuangchuang Talent Project of Jiangsu Province (Grant No. 1102000208).

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Authors and Affiliations

  1. School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro–Nano Biomedical Instruments, Southeast University, Nanjing, 211189, China

    Xiao Li, Man Zhang, Yujie Hu, Jian Xu, Dongke Sun, Tao Hu & Zhonghua Ni

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  1. Xiao Li
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  2. Man Zhang
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  3. Yujie Hu
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  4. Jian Xu
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  5. Dongke Sun
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  6. Tao Hu
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  7. Zhonghua Ni
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Correspondence to Tao Hu or Zhonghua Ni.

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Li, X., Zhang, M., Hu, Y. et al. Screen-printed electrochemical biosensor based on a ternary Co@MoS2/rGO functionalized electrode for high-performance non-enzymatic glucose sensing. Biomed Microdevices 22, 17 (2020). https://doi.org/10.1007/s10544-020-0472-z

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